Beilstein J. Org. Chem.2022,18, 1567–1574, doi:10.3762/bjoc.18.167
involved a highly reactive difluoroethylene intermediate, which was produced by the reaction between halothane and KOH.
Keywords: aryl 1-monofluorovinyl ether; electrophilic 1,1-difluoroethene; halothane; multi-halogenatedalkene; phenol; Introduction
2-Bromo-2-chloro-1,1,1-trifluoroethane (halothane
experiments were carried out under argon atmosphere in flame-dried glassware using standard inert techniques for introducing reagents and solvents unless otherwise noted.
Typical procedures for synthesis of multi-halogenatedalkene
Ground KOH (5.0 mmol) was added to a solution of phenol (1.0 mmol) in DME (5.0
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Graphical Abstract
Figure 1:
Medicines containing a difluoromethylene group.